Comparative transcriptome of normal and cancer-associated fibroblasts.

ABSTRACT:

Background

The characteristics of a tumor are largely determined by its interaction with the surrounding micro-environment (TME). TME consists of both cellular and non-cellular components. Cancer-associated fibroblasts (CAFs) are a major component of the TME. They are a source of many secreted factors that influence the survival and progression of tumors as well as their response to drugs. Identification of markers either overexpressed in CAFs or unique to CAFs would pave the way for novel therapeutic strategies that in combination with conventional chemotherapy are likely to have better patient outcome.

Methods

Fibroblasts have been derived from Benign Prostatic Hyperplasia (BPH) and prostate cancer. RNA from these has been used to perform a transcriptome analysis in order

SUBMITTER: Abikar A 

PROVIDER: S-EPMC11456241 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature