From pre-clinical to translational brain metastasis research: current challenges and emerging opportunities.

ABSTRACT: Brain metastasis, characterized by poor clinical outcomes, is a devastating disease. Despite significant mechanistic and therapeutic advances in recent years, pivotal improvements in clinical interventions have remained elusive. The heterogeneous nature of the primary tumor of origin, complications in drug delivery across the blood-brain barrier, and the distinct microenvironment collectively pose formidable clinical challenges in developing new treatments for patients with brain metastasis. Although current preclinical models have deepened our basic understanding of the disease, much of the existing research on brain metastasis has employed a reductionist approach. This approach, which often relies on either in vitro systems or in vivo injection models in young and treatment-naive mouse m

SUBMITTER: Aleksandrovic E 

PROVIDER: S-EPMC11456321 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature