Increased neutrophil counts are associated with poor overall survival in patients with colorectal cancer: a five-year retrospective analysis.

ABSTRACT:

Background

Colorectal cancer (CRC) continues to be a major health concern in today's world. Despite conflictive findings, evidence supports systemic inflammation's impact on CRC patients' survival rates. Therefore, this study aims to assess the prognostic role of the innate immune system in patients with CRC.

Method

A total of 449 patients were included, with a 5-year follow-up period, and absolute neutrophil counts and their related ratios were measured.

Results

The non-survival group had increased levels of white blood cells, neutrophils (both p<0.001), and monocytes (p=0.038), compared to the survival group, along with other neutrophil-related ratios. We observed increased mortality risk in patients in the highest tertile of white blood cells [HR=1.85 (1.09-

SUBMITTER: Garcia-Flores LA 

PROVIDER: S-EPMC11456424 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature