Rapid diagnosis of <i>Aspergillus flavus</i> infection in acute very severe aplastic anemia with metagenomic next-generation sequencing: a case report and literature review.

ABSTRACT: Infection remains the leading cause of mortality in severe aplastic anemia (SAA) patients, with invasive fungal infections being the great threat. Aspergillus fumigatus accounts for most of the reported fungal infection cases. Here, we present a case of A. flavus infection in a patient with acute very severe aplastic anemia (VSAA) despite persistently negative clinical fungal tests. The patient was admitted to the hospital due to pancytopenia presisting for over a month and intermittent fever for 10 days. Elevated inflammatory indicators and abnormal lung imaging suggested infection, prompting consideration of fungal involvement. Despite negative results from multiple blood, sputum fungal cultures and the serum (1,3)-β-D-glucan/galactomannan tests. Metagenomic next-generation

SUBMITTER: Kang Y 

PROVIDER: S-EPMC11456449 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature