Gut microbiota and functional outcome after ischemic stroke: a Mendelian randomization study.

ABSTRACT:

Background

Previous studies have shown that gut microbiota dysbiosis could affect clinical prognosis through an unknown mechanism. However, the causal relationship between the gut microbiota and the functional outcome after ischemic stroke remains unclear. We aimed to investigate the causal association between the gut microbiota and the functional outcome after ischemic stroke using Mendelian randomization (MR).

Methods

Genetic instrumental variables associated with 211 bacterial traits were obtained from the MiBioGen consortium (N = 18,340). Data from genome-wide association studies (GWAS) for functional outcome after ischemic stroke were obtained from two phenotypes (i.e., overall stroke outcome and motor recovery). The inverse variance weighted method was used to e

SUBMITTER: Qu D 

PROVIDER: S-EPMC11456476 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature