FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury.

ABSTRACT:

Introduction

Ferroptosis is a new type of cell death characterized by lipid peroxidation and iron dependency, representing an emerging disease regulation mechanism. The limited understanding of ferroptosis in peripheral nerve injury (PNI) complicates the management of such injuries. Mitochondrial dysfunction, which contributes to ferroptosis, further exacerbates the challenges of peripheral nerve repair.

Methods

In this study, we established an in vitro model of Schwann cells model treated with TBHP and an in vivo sciatic nerve crush injury model in rats. These models were used to investigate the effects of fibroblast growth factor 21 (FGF21) on PNI, both in vitro and in vivo, and to explore the potential mechanisms linking injury-induced ferroptosis and mitochondrial dysfun

SUBMITTER: Yan Y 

PROVIDER: S-EPMC11456482 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature