Cacna1c deficiency in forebrain glutamatergic neurons alters behavior and hippocampal plasticity in female mice.

ABSTRACT: CACNA1C, coding for the α1 subunit of L-type voltage-gated calcium channel (LTCC) Ca_v1.2, has been associated with multiple psychiatric disorders. Clinical studies have revealed alterations in behavior as well as in brain structure and function in CACNA1C risk allele carriers. These findings are supported by rodent models of Ca_v1.2 deficiency, which showed increased anxiety, cognitive and social impairments as well as a shift towards active stress-coping strategies. These behavioral alterations were accompanied by functional deficits, such as reduced long-term potentiation (LTP) and an excitation/inhibition (E/I) imbalance. However, these preclinical studies are largely limited to male rodents, with few studies exploring sex-specific effects. Here, we investigated the

SUBMITTER: Loganathan S 

PROVIDER: S-EPMC11456591 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature