Mapping individual cortico-basal ganglia-thalamo-cortical circuits integrating structural and functional connectome: implications for upper limb motor impairment poststroke.

ABSTRACT: This study investigated alterations in functional connectivity (FC) within cortico-basal ganglia-thalamo-cortical (CBTC) circuits and identified critical connections influencing poststroke motor recovery, offering insights into optimizing brain modulation strategies to address the limitations of traditional single-target stimulation. We delineated individual-specific parallel loops of CBTC through probabilistic tracking and voxel connectivity profiles-based segmentation and calculated FC values in poststroke patients and healthy controls, comparing with conventional atlas-based FC calculation. Support vector machine (SVM) analysis distinguished poststroke patients from controls. Connectome-based predictive modeling (CPM) used FC values within CBTC circuits to predict upper limb motor funct

SUBMITTER: Xue X 

PROVIDER: S-EPMC11456677 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature