Oral mucosa effectively protects against peanut allergy in mice.

ABSTRACT:

Background

Oral consumption of peanut products early in life reduces the incidence of peanut allergy in children. However, little is known about whether exposure via the oral mucosa alone is sufficient or whether the gastrointestinal tract must be engaged to protect against peanut allergy.

Objective

We used a mouse model and examined the effects of peanut allergen administration to only the oral cavity on allergy development induced by environmental exposure.

Methods

Naive BALB/c mice were administered peanut flour (PNF) sublingually, followed by epicutaneous exposure to PNF to mimic a human condition. The sublingual volume was adjusted to engage only the oral cavity and prevent it from reaching the esophagus or gastrointestinal tract. The efficacy was evaluated by ex

SUBMITTER: Yoshida Y 

PROVIDER: S-EPMC11456774 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature