Obesity induces PD-1 on macrophages to suppress anti-tumour immunity.

ABSTRACT: Obesity is a leading risk factor for progression and metastasis of many cancers^1,2, yet can in some cases enhance survival^3-5 and responses to immune checkpoint blockade therapies, including anti-PD-1, which targets PD-1 (encoded by PDCD1), an inhibitory receptor expressed on immune cells^6-8. Although obesity promotes chronic inflammation, the role of the immune system in the obesity-cancer connection and immunotherapy remains unclear. It has been shown that in addition to T cells, macrophages can express PD-1^9-12. Here we found that obesity selectively induced PD-1 expression on tumour-associated macrophages (TAMs). Type I inflammatory cytokines and molecules linked to obesity, including interferon-γ, tumour necrosis factor, leptin, insulin and

SUBMITTER: Bader JE 

PROVIDER: S-EPMC11456854 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature