Investigating the active components and mechanistic effects of <i>Forsythia suspensa</i> Leaf against RSV via the PI3K/Akt-NLRP3 pathway.

ABSTRACT:

Background

Pulmonary infections resulting from respiratory syncytial virus (RSV) continue to pose a significant threat to the well-being of infants and the elderly, but there is no safe, effective and specific treatment except symptomatic treatment. Forsythia Suspensa Leaf (FSL) is cold in nature and bitter in taste, and has the efficacy of clearing away heat and toxic materials. Previous research by our research group showed that the active components in FSL have the pharmacological effect of anti-RSV. Based on that, this study aims further to clarify the anti-RSV active components and mechanism of FSL.

Methods

Firstly, we established the BALB/c mouse model of RSV infection, assessed the in vivo anti-RSV efficacy, and determined the optimal dosage of FSL and i

SUBMITTER: Wang X 

PROVIDER: S-EPMC11456894 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature