Characterizing the Racial Discrepancy in Hypoxemia Detection in Venovenous Extracorporeal Membrane Oxygenation: An Extracorporeal Life Support Organization Registry Analysis.

ABSTRACT:

Purpose

Skin pigmentation influences peripheral oxygen saturation (SpO₂) compared to arterial saturation of oxygen (SaO₂). Occult hypoxemia (SaO₂ ≤ 88% with SpO₂ ≥ 92%) is associated with increased in-hospital mortality in venovenous-extracorporeal membrane oxygenation (VV-ECMO) patients. We hypothesized VV-ECMO cannulation, in addition to race/ethnicity, accentuates the SpO₂-SaO₂ discrepancy due to significant hemolysis.

Methods

Adults (≥ 18 years) supported with VV-ECMO with concurrently measured SpO₂ and SaO₂ measurements from over 500 centers in the Extracorporeal Life Support Organization Registry (1/2018-5/2023) were included. Multivariable logistic regressions were performed to exa

SUBMITTER: Kalra A 

PROVIDER: S-EPMC11456976 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature