HFIP as a versatile solvent in resorcin[<i>n</i>]arene synthesis.

ABSTRACT: Herein, we present 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as an efficient solvent for synthesizing resorcin[n]arenes in the presence of catalytic amounts of HCl at ambient temperature and within minutes. Remarkably, resorcinols with electron-withdrawing groups and halogens, which are reported in the literature as the most challenging precursors in this cyclization, are tolerated. This method leads to a variety of 2-substituted resorcin[n]arenes in a single synthetic step with isolated yields up to 98%.

SUBMITTER: Khosravi H 

PROVIDER: S-EPMC11457071 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature