Genomics of natural populations: gene conversion events reveal selected genes within the inversions of Drosophila pseudoobscura.

ABSTRACT: When adaptive phenotypic variation or quantitative trait loci map within an inverted segment of a chromosome, researchers often despair because the suppression of crossing over will prevent the discovery of selective target genes that established the rearrangement. If an inversion polymorphism is old enough, then the accumulation of gene conversion tracts offers the promise that quantitative trait loci or selected loci within inversions can be mapped. The inversion polymorphism of Drosophila pseudoobscura is a model system to show that gene conversion analysis is a useful tool for mapping selected loci within inversions. D. pseudoobscura has over 30 different chromosomal arrangements on the third chromosome (Muller C) in natural populations and their frequencies vary with changes in enviro

SUBMITTER: Schaeffer SW 

PROVIDER: S-EPMC11457094 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature