The minimal important difference in obsessive-compulsive disorder: An analysis of double-blind SSRI trials in adults.

ABSTRACT:

Background

The change in symptoms necessary to be clinically relevant in obsessive-compulsive disorder (OCD) is currently unknown. In this study, we aimed to create an empirically validated threshold for clinical significance or minimal important difference (MID).

Methods

We analyzed individual participant data from short-term, double-blind, placebo-controlled registration trials of selective serotonin reuptake inhibitors in adult OCD patients. Data were collected from baseline to week 12. We used equipercentile linking to equate changes in the Clinical Global Impression (CGI) scale to changes in the Yale-Brown Obsessive-Compulsive Scale (YBOCS). We defined the MID as the YBOCS change linked to a CGI improvement of 3 (defined as "minimal improvement").

Results

We incl

SUBMITTER: Cohen SE 

PROVIDER: S-EPMC11457115 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature