Trajectories of daily antipsychotic use and weight gain in people hospitalized for the first episode of psychosis.

ABSTRACT:

Background

We need to better understand the risk factors and predictors of medication-related weight gain to improve metabolic health of individuals with schizophrenia. This study explores how trajectories of antipsychotic medication (AP) use impact body weight early in the course of schizophrenia.

Methods

We recruited 92 participants with first-episode psychosis (FEP, n = 92) during their first psychiatric hospitalization. We prospectively collected weight, body mass index (BMI), metabolic markers, and exact daily medication exposure during 6-week hospitalization. We quantified the trajectory of AP medication changes and AP polypharmacy using a novel approach based on meta-analytical ranking of medications and tested it as a predictor of weight gain together with tra

SUBMITTER: Vochoskova K 

PROVIDER: S-EPMC11457116 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature