Association of cardiometabolic multimorbidity with risk of late-life depression: a nationwide twin study.

ABSTRACT:

Background

Cardiometabolic diseases (CMDs) including heart disease, stroke, and type 2 diabetes have been individually linked to depression. However, their combined impact on depression risk is unclear. We aimed to examine the association between cardiometabolic multimorbidity and depression and explore the role of genetic background in this association.

Methods

Within the Swedish Twin Registry, 40,080 depression-free individuals (mean age 60 years) were followed for 18 years. Cardiometabolic multimorbidity was defined as having ≥2 CMDs. CMDs and depression were ascertained based on the National Patient Register. Cox regression was used to estimate the CMD-depression association in a classical cohort study design and a matched co-twin design involving 176 twin pairs. By comp

SUBMITTER: Yang W 

PROVIDER: S-EPMC11457118 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature