Enhancement of Subcutaneous Islet Transplant Performance by Collagen 1 Gel.

ABSTRACT: Human islets can be transplanted into the portal vein for T1 diabetes, and a similar procedure is being used in a clinical trial for stem cell-derived beta-like cells. Efforts have been underway to find an alternative transplant site that will foster better islet cell survival and function. Although conceptually attractive, the subcutaneous (SC) site has yielded disappointing results, in spite of some improvements resulting from more attention paid to vascularization and differentiation factors, including collagen. We developed a method to transplant rat islets in a disk of type 1 collagen gel and found improved efficacy of these transplants. Survival of islets following transplantation (tx) was determined by comparing insulin content of the graft to that of the pre-transplant islets from

SUBMITTER: French A 

PROVIDER: S-EPMC11457190 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature