Identification of key ubiquitination-related genes in gestational diabetes mellitus: A bioinformatics-driven study.

ABSTRACT:

Background and aims

Gestational diabetes mellitus (GDM) is characterized by glucose intolerance that occurs during pregnancy. This study aimed to identify key ubiquitination-related genes associated with GDM pathogenesis.

Methods

Microarray data from GSE154377 was analyzed to identify differentially expressed genes (DEGs) in GDM vs normal pregnancy samples. Weighted gene co-expression network analysis was performed on ubiquitination-related genes. Functional enrichment, protein-protein interaction network, and TF-mRNA-miRNA interaction network analyses were conducted on differentially expressed ubiquitination-related genes (DE-URGs).

Results

We identified 2337 DEGs and 65 DE-URGs in GDM. Functional enrichment analysis of the 65 DE-URGs revealed involvement in protein

SUBMITTER: Dai Y 

PROVIDER: S-EPMC11457210 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature