Associations between acute kidney injury and bone fractures: a retrospective cohort study.

ABSTRACT:

Background

Acute kidney injury (AKI) is common. An AKI episode may disrupt the normal mineral bone balance maintained by normal kidney function, thereby modifying the risk of developing bone fractures. However, it remains unclear whether an AKI episode is associated with the risk of bone fractures.

Methods

Using retrospective cohort study from an Australian Local Health District, we examined the association between an AKI episode and bone fractures using patient data between 2008 and 2017. Time-varying Cox proportional hazards and propensity-matched analysis were used to examine the association. Sensitivity analyses were undertaken to capture the impact of confirmed AKI status and AKI severity.

Results

Of 123 426 included patients, 14 549 (12%) had an AKI episode and

SUBMITTER: Cheikh Hassan HI 

PROVIDER: S-EPMC11457262 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature