Immunologic and Epidemiologic Drivers of Norovirus Transmission in Daycare and School Outbreaks.

ABSTRACT:

Background

Norovirus outbreaks are notoriously explosive, with dramatic symptomology and rapid disease spread. Children are particularly vulnerable to infection and drive norovirus transmission due to their high contact rates with each other and the environment. Despite the explosive nature of norovirus outbreaks, attack rates in schools and daycares remain low with the majority of students not reporting symptoms.

Methods

We explore immunologic and epidemiologic mechanisms that may underlie epidemic norovirus transmission dynamics using a disease transmission model. Towards this end, we compared different model scenarios, including innate resistance and acquired immunity (collectively denoted 'immunity'), stochastic extinction, and an individual exclusion intervention. We ca

SUBMITTER: Havumaki J 

PROVIDER: S-EPMC11457302 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature