Interferon regulatory factor 7 alleviates the experimental colitis through enhancing IL-28A-mediated intestinal epithelial integrity.

ABSTRACT:

Background

The incidence of inflammatory bowel disease (IBD) is on the rise in developing countries, and investigating the underlying mechanisms of IBD is essential for the development of targeted therapeutic interventions. Interferon regulatory factor 7 (IRF7) is known to exert pro-inflammatory effects in various autoimmune diseases, yet its precise role in the development of colitis remains unclear.

Methods

We analyzed the clinical significance of IRF7 in ulcerative colitis (UC) by searching RNA-Seq databases and collecting tissue samples from clinical UC patients. And, we performed dextran sodium sulfate (DSS)-induced colitis modeling using WT and Irf7^-/- mice to explore the mechanism of IRF7 action on colitis.

Results

In this study, we found that IRF7 e

SUBMITTER: Qing F 

PROVIDER: S-EPMC11457333 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature