Effect of inflammatory factors on myocardial infarction.

ABSTRACT:

Background

Cohort studies have increasingly shown associations between inflammatory markers and myocardial infarction (MI); however, the specific causal relationships between inflammatory markers and the development of MI remain unclear.

Methods and results

By utilizing publicly accessible genome-wide association studies, we performed a two-sample Mendelian randomization (MR) analysis to explore the causal associations between inflammatory markers and myocardial infarction (MI). A random-effects inverse-variance weighted method was used to calculate effect estimates. The study included a total of 395,795 European participants for MI analysis and various sample sizes for inflammatory factors, ranging from 3,301 to 563,946 participants.Neutrophil count was found to increase th

SUBMITTER: Zeng Q 

PROVIDER: S-EPMC11457337 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature