Role of interferon-gamma release assay for screening and monitoring of latent tuberculosis infection in kidney transplant recipients.

ABSTRACT:

Background

The reactivation of tuberculosis (TB) among kidney transplant (KT) recipients in an endemic area is of general concern. However, the epidemiology of latent TB infection (LTBI) status and its dynamic change responses have not been explored.

Methods

Between September 2020 and August 2021, a prospective study was conducted to investigate the status of LTBI in KT recipients who received a 9-month isoniazid universal prophylaxis. This status was measured using the interferon-gamma release assay (IGRA) with T-SPOT.TB before transplant, as well as at one month and nine months post-transplant.

Results

Ninety-one KT recipients had a mean (SD) age of 45 (11) years, and 41% were female. Sixty-eight (75%) patients received a deceased donor allograft, and eighty-six (91

SUBMITTER: Bruminhent J 

PROVIDER: S-EPMC11457419 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature