Assessing the causal relationship between non-small cell lung cancer and sepsis: a Mendelian randomization study.

ABSTRACT:

Background

A Two-sample Mendelian randomization (MR) Analysis was used to assess the causal relationship between non-small cell lung cancer (NSCLC) and sepsis.

Method

Single nucleotide polymorphisms (SNPs) closely associated with NSCLC were utilized as instrumental variables (IVs) in this study. The Inverse Variance Weighted (IVW) method was used as the primary method for MR analysis, supplemented by the Weighted median, Weighted model, and MR-Egger regression method. Sensitivity analysis was conducted to improve result robustness, and data from various sources were validated and integrated. Bonferroni tests were applied to adjust for multiple comparisons.

Results

After Bonferroni tests correcting the combined results, MR analysis revealed a significant association be

SUBMITTER: Cheng H 

PROVIDER: S-EPMC11457449 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature