FGF-stimulated tendon cells embrace a chondrogenic fate with BMP7 in newt tissue culture.

ABSTRACT: Newts can regenerate functional elbow joints after amputation at the joint level. Previous studies have suggested the potential contribution of cells from residual tendon tissues to joint cartilage regeneration. A serum-free tissue culture system for tendons was established to explore cell dynamics during joint regeneration. Culturing isolated tendons in this system, stimulated by regeneration-related factors, such as fibroblast growth factor (FGF) and platelet-derived growth factor, led to robust cell migration and proliferation. Moreover, cells proliferating in an FGF-rich environment differentiated into Sox9-positive chondrocytes upon BMP7 introduction. These findings suggest that FGF-stimulated cells from tendons may aid in joint cartilage regeneration during functional elbow joint reg

SUBMITTER: Sugiura N 

PROVIDER: S-EPMC11457504 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature