Outcomes from low-risk ductal carcinoma in situ: a systematic review and meta-analysis.

ABSTRACT:

Purpose

The current standard of treatment for ductal carcinoma in situ (DCIS) is surgery with or without adjuvant radiotherapy. With a growing debate about overdiagnosis and overtreatment of low-risk DCIS, active surveillance is being explored in several ongoing trials. We conducted a systematic review and meta-analysis to evaluate the recurrence of low-risk DCIS under various treatment approaches.

Methods

PubMed, Embase, Web of Science, and Cochrane were searched for studies reporting ipsilateral breast tumour event (IBTE), contralateral breast cancer (CBC), and breast cancer-specific survival (BCSS) rates at 5 and 10 years in low-risk DCIS. The primary outcome was invasive IBTE (iIBTE) defined as invasive progression in the ipsilateral breast.

Results

Thirty three e

SUBMITTER: Chen Q 

PROVIDER: S-EPMC11457553 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature