Changes in immune status of circulating NK cells in patients with latent tuberculosis infection.

ABSTRACT:

Introduction

The presence of patients with latent tuberculosis infection (LTBI) has fueled the tuberculosis pandemic. We aimed to investigate the immune status of NK cells in LTBI patients.

Material and methods

Twenty-one LTBI patients, 25 active pulmonary tuberculosis (APTB) patients and 25 healthy controls (HCs) participated in our research. The markers of NK cells were detected by flow cytometry.

Results

The absolute number of circulating CD56bright and CD56dim NK cells in LTBI patients was higher than that of APTB patients, but the frequency of HLA-DR+ CD56bright NK cells was significantly lower than that of HCs and APTB patients. Also, LTBI patients with CD56bright NK cells had intracellular levels of granzyme B that were as significantly elevated as those with A

SUBMITTER: Qin S 

PROVIDER: S-EPMC11457571 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature