Investigation of health care use and a possible prodrome before the first attack in NMOSD and MOGAD.

ABSTRACT:

Background

Prodromal phases are well recognized in many inflammatory and neurodegenerative diseases, including multiple sclerosis. We evaluated the possibility of a prodrome in aquaporin-4 antibody positive (AQP4+) neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) using health administrative data.

Methods

We investigated individuals with AQP4 + NMOSD and MOGAD, confirmed by medical chart review, in Ontario, Canada. Each NMOSD and MOGAD participant was matched 1:5 to general population controls by sex, birth year, immigrant status, and region. Total outpatient visits and hospitalizations were compared in the 5 years preceding the incident attack in multivariable negative binomial models.

Results

We identifie

SUBMITTER: Rotstein DL 

PROVIDER: S-EPMC11457589 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature