Synthesis of quercetin derivatives as cytotoxic against breast cancer MCF-7 cell line <i>in vitro</i> and <i>in silico</i> studies.

ABSTRACT: Background: Quercetin being antioxidant and antiproliferative agent acts by inhibiting CDK2, with an increase in cancer prevalence there is a need to profile quercetin derivatives as CDK2 inhibitors.Materials & method: Schiff bases of quercetin were synthesized as cytotoxic agents against the MCF7 cell line. FTIR, ¹H-NMR and ¹³C-NMR, CHNS/O analysis were employed along with in vivo and in silico activities.Results & conclusion: 2q, 4q, 8q and 9q derivatives have maximum cytotoxic effect with IC₅₀ values 39.7 ± 0.7, 36.65 ± 0.25, 35.49 ± 0.21 and 36.99 ± 0.45, respectively. Molecular docking also confirmed these results 8q has the highest binding potential of -9.165 KJ/mole making it a potent inhibitor of CDK2. These deriva

SUBMITTER: Khan MR 

PROVIDER: S-EPMC11457645 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature