Effect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates.

ABSTRACT: Current antiretroviral therapy (ART) regimens efficiently limit HIV replication, thereby improving the life expectancy of people living with HIV; however, they also cause metabolic side effects. The ongoing obesity epidemic has resulted in more people with metabolic comorbidities at the time of HIV infection, yet the effect of preexisting metabolic dysregulation on infection sequelae and response to ART is unclear. Here, to investigate the impact of preexisting obesity and insulin resistance on acute infection and subsequent long-term ART, we infected a cohort of lean and obese adult male macaques with SIV and administered ART. The responses of lean and obese macaques to SIV and ART were similar with respect to plasma and cell-associated viral loads, ART drug levels in plasma and tissues,

SUBMITTER: Webb GM 

PROVIDER: S-EPMC11457846 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature