Predictors of Discordance Between Dry Eye Symptoms and Signs: Insights From the Sjogren's International Collaborative Clinical Alliance.

ABSTRACT:

Purpose

The diagnosis and management of dry eye disease (DED) could be complicated by the discordance between DED-related symptoms and signs. We performed a cross-sectional study to investigate the factors of and develop predictive models for the discrepancy in DED symptomatology.

Methods

We used data from 3455 participants, 21 to 89 years old, from the Sjögren's International Collaborative Clinical Alliance study. We performed a multivariable stepwise linear regression model with backward elimination and Bayesian information criteria to select predictors for the discordance in DES symptomatology, which was defined as the difference between the rank score of Ocular Surface Disease Index 6 (OSDI-6) and the rank score of ocular staining score (OSS).

Results

Ten predicto

SUBMITTER: Xiong F 

PROVIDER: S-EPMC11457922 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature