Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia.

ABSTRACT:

Purpose

Although cure rates for childhood acute lymphoblastic leukemia (ALL) exceed 90%, ALL remains a leading cause of cancer death in children. Half of relapses arise in children initially classified with standard-risk (SR) disease.

Materials and methods

To identify genomic determinants of relapse in children with SR ALL, we performed genome and transcriptome sequencing of diagnostic and remission samples of children with SR (n = 1,381) or high-risk B-ALL with favorable cytogenetic features (n = 115) enrolled on Children's Oncology Group trials. We used a case-control study design analyzing 439 patients who relapsed and 1,057 who remained in complete remission for at least 5 years.

Results

Genomic subtype was associated with relapse, which occurred in approximately

SUBMITTER: Chang TC 

PROVIDER: S-EPMC11458106 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature