Central Lean Mass Distribution and the Risks of All-Cause and Cause-Specific Mortality in 40,283 UK Biobank Participants.

ABSTRACT:

Introduction

The purpose of this study was to investigate the association of central lean mass distribution with the risk of mortality.

Methods

This cohort study included 40,283 UK Biobank participants. Cox proportional hazards regression models were used to estimate the association of central lean mass distribution, i.e., trunk-to-leg lean mass ratio, assessed by dual-energy X-ray absorptiometry, with the risk of mortality.

Results

The median age of the participants was 65 years, and 52% were women. During a median follow-up of 4.18 years, 674 participants died, of whom 366 were due to cancer and 126 were due to cardiovascular causes. Compared with the lowest tertile of a trunk-to-leg lean mass ratio, the multivariable-adjusted (age, sex, ethnicity, lifestyle, comorb

SUBMITTER: Ding L 

PROVIDER: S-EPMC11458161 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature