Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3.

ABSTRACT: Most malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3, but deletions of pfhrp2 and phfrp3 genes make parasites undetectable by RDTs. We analyzed 19,313 public whole-genome-sequenced P. falciparum field samples to understand these deletions better. Pfhrp2 deletion only occurred by chromosomal breakage with subsequent telomere healing. Pfhrp3 deletions involved loss from pfhrp3 to the telomere and showed three patterns: no other associated rearrangement with evidence of telomere healing at breakpoint (Asia; Pattern 13^-TARE1); associated with duplication of a chromosome 5 segment containing multidrug-resistant-1 gene (Asia; Pattern 13^-5⁺⁺); and most

SUBMITTER: Hathaway NJ 

PROVIDER: S-EPMC11458181 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature