An Integrated Signaling Threshold Initiates IgG Response toward Virus-like Immunogens.

ABSTRACT: Class-switched neutralizing Ab (nAb) production is rapidly induced upon many viral infections. However, due to the presence of multiple components in virions, the precise biochemical and biophysical signals from viral infections that initiate nAb responses remain inadequately defined. Using a reductionist system of synthetic virus-like structures, in this study, we show that a foreign protein on a virion-sized liposome can serve as a stand-alone danger signal to initiate class-switched nAb responses without T cell help or TLR but requires CD19. Introduction of internal nucleic acids (iNAs) obviates the need for CD19, lowers the epitope density (ED) required to elicit the Ab response, and transforms these structures into highly potent immunogens that rival conventional virus-like particles

SUBMITTER: Wholey WY 

PROVIDER: S-EPMC11458362 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature