Co-regulation of innate and adaptive immune responses induced by ID93+GLA-SE vaccination in humans.

ABSTRACT:

Introduction

Development of an effective vaccine against tuberculosis is a critical step towards reducing the global burden of disease. A therapeutic vaccine might also reduce the high rate of TB recurrence and help address the challenges of drug-resistant strains. ID93+GLA-SE is a candidate subunit vaccine that will soon be evaluated in a phase 2b efficacy trial for prevention of recurrent TB among patients undergoing TB treatment. ID93+GLA-SE vaccination was shown to elicit robust CD4+ T cell and IgG antibody responses among recently treated TB patients in the TBVPX-203 Phase 2a study (NCT02465216), but the mechanisms underlying these responses are not well understood.

Methods

In this study we used specimens from TBVPX-203 participants to describe the changes in peripheral

SUBMITTER: Fiore-Gartland A 

PROVIDER: S-EPMC11458388 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature