Characterisation and Immunogenicity of <i>Neisseria cinerea</i> outer membrane vesicles displaying NadA, NHBA and fHbp from <i>Neisseria meningitidis</i> serogroup B.

ABSTRACT: More affordable and effective vaccines against bacterial meningitis caused by Neisseria meningitidis serogroup B are still required for global prevention. We have previously shown that modified outer membrane vesicles (mOMVs) from commensal Neisseria cinerea can be used as a platform to induce immune responses against meningococcal antigens. The aim of the present study was to use a combination of two genetically engineered mOMVs to express multiple antigens from N. meningitidis known to be involved in protective immunity to meningococcal meningitis (different variants of factor H binding protein (fHbp), Neisseria Heparin Binding Antigen (NHBA) and Neisseria Adhesin A (NadA)). Antigen expression in the mOMVs was confirmed by Western blotting; detoxificati

SUBMITTER: Manoharan S 

PROVIDER: S-EPMC11458423 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature