Machine learning-based discovery of UPP1 as a key oncogene in tumorigenesis and immune escape in gliomas.

ABSTRACT:

Introduction

Gliomas are the most common and aggressive type of primary brain tumor, with a poor prognosis despite current treatment approaches. Understanding the molecular mechanisms underlying glioma development and progression is critical for improving therapies and patient outcomes.

Methods

The current study comprehensively analyzed large-scale single-cell RNA sequencing and bulk RNA sequencing of glioma samples. By utilizing a series of advanced computational methods, this integrative approach identified the gene UPP1 (Uridine Phosphorylase 1) as a novel driver of glioma tumorigenesis and immune evasion.

Results

High levels of UPP1 were linked to poor survival rates in patients. Functional experiments demonstrated that UPP1 promotes tumor cell proliferation and i

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11458454 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature