Pathogen detection by targeted next-generation sequencing test in adult hematological malignancies patients with suspected infections.

ABSTRACT:

Background

Infections in patients with hematological malignancies (HM) are a significant cause of morbidity and mortality. Timely and effective empirical anti-infective treatment can reduce the infection-related mortality rate. Targeted next-generation sequencing (tNGS) offers a rapid diagnostic approach for identifying diverse pathogens in these patients. However, relevant research is still limited to adult patients with HM.

Methods

We conducted a retrospective analysis of adult HM patients admitted to our hospital from March 2023 to September 2023, focusing on their clinical characteristics and the results of both tNGS and conventional microbiological tests (CMTs). We evaluated the performance of tNGS and CMTs in pathogenic diagnosis and described the distribution characte

SUBMITTER: Xu JH 

PROVIDER: S-EPMC11458473 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature