High Serum miR-361-3p Predicts Early Postdischarge Infections after Autologous Stem Cell Transplantation.

ABSTRACT:

Background

Autologous hematopoietic stem cell transplantation (AHSCT) is currently the backbone of the treatment of multiple myeloma (MM) and relapsed and refractory lymphomas. Notably, infections contribute to over 25% of fatalities among AHSCT recipients within the initial 100 days following the procedure. In this study, we aimed to evaluate three selected miRNAs: hsa-miR-155-5p, hsa-miR-320c, and hsa-miR-361-3p, in identifying AHSCT recipients at high risk of infectious events up to 100 days post-transplantation after discharge.

Materials and methods

The study group consisted of 58 patients (43 with MM, 15 with lymphoma) treated with AHSCT. Blood samples were collected from all patients at the same time point: on day +14 after transplantation.

Results

Fifteen patie

SUBMITTER: Mikulski D 

PROVIDER: S-EPMC11458496 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature