Characteristics of isoniazid-induced psychosis: a systematic review of case reports and case series.

ABSTRACT:

Purpose

Isoniazid, a first-line antitubercular drug, is associated with nervous system adverse drug reactions such as seizures, peripheral neuropathy, and psychosis. This systematic review of case reports and case series aimed to characterize the demographic, social, and clinical factors associated with isoniazid-induced psychosis in patients with active tuberculosis (TB) and those who received isoniazid for latent TB infection (LTBI).

Methods

We comprehensively searched the Embase, PubMed, and Scopus databases to identify relevant studies published between the date of inception of the database and June 2024.

Results

A total of 28 studies, including 21 case reports and 7 case series involved 37 patients who developed isoniazid-induced psychosis. A higher frequency of

SUBMITTER: B K 

PROVIDER: S-EPMC11458663 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature