Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow.

ABSTRACT: Hyperemia in response to neural activity is essential for brain health. A hyperemic response delivers O₂ and nutrients, clears metabolic waste, and concomitantly exposes cerebrovascular endothelial cells to hemodynamic forces. While neurovascular research has primarily centered on the front end of hyperemia-neuronal activity-to-vascular response-the mechanical consequences of hyperemia have gone largely unexplored. Piezo1 is an endothelial mechanosensor that senses hyperemia-associated forces. Using genetic mouse models and pharmacologic approaches to manipulate endothelial Piezo1 function, we evaluated its role in blood flow control and whether it impacts cognition. We provide evidence of a built-in brake system that sculpts hyperemia, and specifically show that Piezo1 activati

SUBMITTER: Lim XR 

PROVIDER: S-EPMC11458797 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature