Similarities of metabolomic disturbances in prematurity-associated obstructive lung disease to chronic obstructive pulmonary disease.

ABSTRACT: Prematurity-associated lung disease (PLD) is a long-term consequence of preterm-birth. Since the underlying mechanisms of PLD remain poorly characterised, we compared the urinary metabolome between recently described spirometry phenotypes of PLD. Preterm- and term-born children aged 7-12 years, from the Respiratory Health Outcomes in Neonates (RHiNO) cohort, underwent spirometry and urine collection. The urinary metabolome was analysed by gas chromatography time-of-flight mass spectrometry. Preterm-born children were classified into phenotypes of prematurity-associated obstructive lung disease (POLD, Forced expiratory volume in 1 s (FEV₁) < lower limit of normal (LLN), FEV₁/Forced Vital Capacity (FVC) < LLN), prematurity-associated preserved ratio impaired spirometry

SUBMITTER: Course CW 

PROVIDER: S-EPMC11458810 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature