Vascular Aging in the Choroid Plexus: A 7T Ultrasmall Superparamagnetic Iron Oxide (USPIO)-MRI Study.

ABSTRACT:

Background

The choroid plexus (ChP), a densely vascularized structure, has drawn increasing attention for its involvement in brain homeostasis and waste clearance. While the volumetric changes have been explored in many imaging studies, few studies have investigated the vascular degeneration associated with aging in the ChP.

Purpose

To investigate the sub-structural characteristics of the ChP, particularly the vascular compartment using high-resolution 7T imaging enhanced with Ferumoxytol, an ultrasmall super-paramagnetic iron oxide, which greatly increase the susceptibility contrast for vessels.

Study type

Prospective.

Subjects

Forty-nine subjects without neurological disorders (age: 21-80 years; 42 ± 17 years; 20 females).

Field strength/sequence

7-T w

SUBMITTER: Sun Z 

PROVIDER: S-EPMC11458823 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature