Prognostic significance of pretreatment PET parameters in inoperable, node-positive NSCLC patients with poor prognostic factors undergoing hypofractionated radiotherapy: a single-institution retrospective study.

ABSTRACT:

Background

Node-positive non-small cell lung cancers (NSCLCs) present a challenge for treatment decisions, particularly in patients ineligible for concurrent chemoradiotherapy (CRT) due to poor performance status and compromised lung function. We aimed to investigate the prognostic value of pretreatment positron emission tomography (PET) parameters in high-risk patients undergoing hypofractionated radiotherapy.

Methods

A retrospective analysis was conducted on 42 consecutive patients with inoperable node-positive NSCLC, who underwent hypofractionated radiotherapy between 2014 and 2021 at a single institution. Clinical, treatment-related, and [¹⁸F]FDG PET-based parameters were correlated with progression-free survival (PFS) and overall survival (OS). Median dichoto

SUBMITTER: Zinn AB 

PROVIDER: S-EPMC11458843 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature