BCAP31 Alleviates Lipopolysaccharide-Mediated Acute Lung Injury via Induction of PINK1/Parkin in Alveolar Epithelial Type II Cell.

ABSTRACT: Background: B-cell receptor-associated protein 31 (BCAP31) has protective effects against alveolar epithelial type II cells (AECII) damage by inhibiting mitochondrial injury in acute lung injury (ALI) induced by lipopolysaccharide (LPS), whereas the precise mechanism is still unclear. It is known that PTEN-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy can remove damaged mitochondria selectively, which may be involved in BCAP31 protection against mitochondrial injury. Methods: In the current study, ALI mice models were established by using surfactant protein C (Sftpc)-BCAP31 transgenic mice (BCAP31^TG mice) and AECII-specific BCAP31 knockout mice (BCAP31^CKO mice) treated with LPS. Results: BCAP31 expression in lung tissue and AECII wer

SUBMITTER: Zhu P 

PROVIDER: S-EPMC11458857 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature