Paracrine FGF1 signaling directs pituitary architecture and size.

ABSTRACT: Organ architecture is established during development through intricate cell-cell communication mechanisms, yet the specific signals mediating these communications often remain elusive. Here, we used the anterior pituitary gland that harbors different interdigitated hormone-secreting homotypic cell networks to dissect cell-cell communication mechanisms operating during late development. We show that blocking differentiation of corticotrope cells leads to pituitary hypoplasia with a major effect on somatotrope cells that directly contact corticotropes. Gene knockout of the corticotrope-restricted transcription factor Tpit results in fewer somatotropes, with less secretory granules and a loss of cell polarity, resulting in systemic growth retardation. Single-cell transcriptomic analyses ident

SUBMITTER: Khetchoumian K 

PROVIDER: S-EPMC11459159 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature