Mechanically adaptive and deployable intracortical probes enable long-term neural electrophysiological recordings.

ABSTRACT: Flexible intracortical probes offer important opportunities for stable neural interfaces by reducing chronic immune responses, but their advances usually come with challenges of difficult implantation and limited recording span. Here, we reported a mechanically adaptive and deployable intracortical probe, which features a foldable fishbone-like structural design with branching electrodes on a temperature-responsive shape memory polymer (SMP) substrate. Leveraging the temperature-triggered soft-rigid phase transition and shape memory characteristic of SMP, this probe design enables direct insertion into brain tissue with minimal footprint in a folded configuration while automatically softening to reduce mechanical mismatches with brain tissue and deploying electrodes to a broader recording

SUBMITTER: Wang S 

PROVIDER: S-EPMC11459173 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature