Suspect Screening Analysis of Pooled Human Serum Samples Using GC × GC/TOF-MS.

ABSTRACT: Humans interact with thousands of chemicals. This study aims to identify substances of emerging concern and in need of human health risk evaluations. Sixteen pooled human serum samples were constructed from 25 individual samples each from the National Institute of Environmental Health Sciences' Clinical Research Unit. Samples were analyzed using gas chromatography (GC) × GC/time-of-flight (TOF)-mass spectrometry (MS) in a suspect screening analysis, with follow-up confirmation analysis of 19 substances. A standard reference material blood sample was also analyzed through the confirmation process for comparison. The pools were stratified by sex (female and male) and by age (≤45 and >45). Publicly available information on potential exposure sources was aggregated to annotate presence in seru

SUBMITTER: Phillips KA 

PROVIDER: S-EPMC11459241 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature